J Sports Med Phys Fitness. One salmon filet contains about half a milligram of astaxanthin, meaning you'd have to chow down on 12 filets in order to get those 6 milligrams. * And a 2020 study found that due to its antioxidant properties, astaxanthin may support overall cardiovascular health . It is recommended that you should take 8 mg of the drug per day, which is equal to 1.6 kg of fresh salmon. Astaxanthin is taken by mouth for treating Alzheimer's disease, Parkinson's disease, stroke, high cholesterol, age-related . Let's explore what you can expect from taking astaxanthin, below. We wont get into all the nerdy metabolic pathways that astaxanthin can impact (if thats your thing, you can read the full review article here). 3. S-adenosyl-L-methionine (SAMe) is a compound found naturally in the body. Cell and animal studies show promising results and we look forward to more research into this exciting area of health! Weve already discussed that astaxanthin is likely safe and has few side effects when taken as directed. It's also a more economical approach, and you receive the astaxanthin benefits minus the potential contaminants from large quantities of fish (e.g., heavy metals). As weve discussed, astaxanthin is an antioxidant that protects against oxidative stress. Specifically, it's a type of carotenoid1, or a natural pigment that gives foods like pumpkin and carrots their red-orange-yellow hue. *These statements have not been evaluated by the Food and Drug Administration. FASEB J 2009;23(6):1958-1968. A 2008 animal study showed that astaxanthin helped protect retinal cells against oxidative damage. Astaxanthin, or any antioxidant, can help fight against this stress. It's also available in natural supplement form. It can also be found in supplement form and is also approved for use as a food coloring in animal and fish feed. You can also get astaxanthin naturally through salmon, but you'd need to eat a lot of it every day to get the recommended amount. Supplement makers may suggest varying amounts of astaxanthin for different purposes. neutralize free radicals at a higher rate than other carotenoids, no documented negative side effects to date, extremely high and chronic intake of beta-carotene, skin inflammatory pathways and photoaging, shown to improve natural hydration levels in the eyes, https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/carotenoids, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917265/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5946307/, https://www.ncbi.nlm.nih.gov/books/NBK534878/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/table/nutrients-10-00522-t001/, https://pubmed.ncbi.nlm.nih.gov/22428137/, https://www.sciencedirect.com/science/article/pii/S1756464621005090?via%3Dihub, https://www.cdc.gov/heartdisease/brain_health.htm, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705074/, https://www.sciencedirect.com/science/article/abs/pii/S0014483520303729?via%3Dihub, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997915/. It also interacts with herbs, including saw palmetto, black cohosh and vitex. Popular brands of naturally derived astaxanthin include BioAstin and Puritans Pride. Nakagawa, K., Kiko, T., Miyazawa, T., Carpentero, Burdeos G., Kimura, F., Satoh, A., and Miyazawa, T. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. Chitchumroonchokchai, C., Bomser, J. One of the largest sources of astaxanthin is in certain types of marine algae. Gastrointestinal: Abdominal pain Blood: Bleeding, low blood sugar levels, low calcium levels, aplastic anemia (lack of red blood cell production. One end of the molecule protects the fat-soluble part of cells. 2002;21:490. In some countries in Europe, SAMe is a prescription drug. Its antioxidant properties exert anti-inflammatory effects, which have been shown to improve natural hydration levels in the eyes11. Health Conditions Featured Breast Cancer IBD Migraine Multiple Sclerosis (MS) Rheumatoid Arthritis Type 2 Diabetes Sponsored Topics Articles. Astaxanthin: 19 Known Medical Benefits, Uses, Side Effects & Conditions - Healthcare Weekly Astaxanthin has proved helpful in the treatment of some diseases such as Alzheimer's, Parkinson's, stroke, high cholesterol and other conditions. Tian L, Wen Y, Li S, et al. And for good reason, toothese antioxidants are crucial for skin health, immune function, and more. Safety and side effects For most healthy people . Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. View abstract. Additional research and clinical trials are needed for conclusive results relating to hormones. Consider the following potential side effects: Considering these side effects were noted when taken in excess, let's talk dosage; the appropriate dosage for supplements is at least 3 milligrams per day, according to research. Progesterone is a hormone found in all people that can play a role in increasing appetite and metabolism. View abstract. Here's how that shakes out in published science: According to a 2021 scientific review, as astaxanthin exerts antioxidant effects, it may also help promote healthy blood pressure 8 . Information from this source is evidence-based and objective, and without commercial influence. Another study comprising 48 adults complaining of eye strain found that a supplement containing several nutrients, including astaxanthin, helped reduce symptoms of eye fatigue. 9-28-2009;283(1):108-117. Gharaei R, Alyasin A, Mahdavinezhad F, Samadian E, Ashrafnezhad Z, Amidi F. Randomized controlled trial of astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. View abstract. Karppi et al. View abstract. Although studies in humans are limited, current research suggests that astaxanthin benefits brain and heart health, endurance and energy levels, and even fertility. Video: Why You Need Zinc and Where to Find It. 2007;50:244-48. Eyes also incur damage from ultraviolet light exposure. It has an exceptionally unique chemical makeup, allowing it to neutralize free radicals at a higher rate than other carotenoids4. In men and those with penises, progesterone plays a role in sperm and testosterone production. View abstract. . J Am Coll Nutr. Nihon Ganka Gakkai Zasshi 2009;113(3):403-422. 2002;21:489. Is Garcinia Cambogia Safe for Weight Loss? It does not appear to have a negative impact on the liver, kidney, or hormone health. Tinkler, J. H., Bohm, F., Schalch, W., and Truscott, T. G. Dietary carotenoids protect human cells from damage. * (We've all been there!). Use with caution if you are taking a drug that affects hormones, such as a 5-alpha-reductase inhibitor, or if you are on a drug for high blood pressure. However, the recommended dosage can vary by country and has been found to range between 2 and 24 mg per day. In one animal study, astaxanthin restored both testosterone and progesterone production in leydig cells (found in the testes) exposed to oxidative stress. OTHER NAME(S): Astaxanthine, Astaxantina, Dihydroxy-3,3 dioxo-4, Astaxanthin has most often been used by adults in doses of 4-18 mg by, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, The Role Gut Bacteria Plays on the Overall Body. Nishigaki, I., Rajendran, P., Venugopal, R., Ekambaram, G., Sakthisekaran, D., and Nishigaki, Y. Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells. No need to be concerned about astaxanthin and liver health! Overall, astaxanthin is a safe supplement for most people. Pashkow, F. J., Watumull, D. G., and Campbell, C. L. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. 2008;46(3):283-290. Int J Environ Res Public Health 2022;19(20):13492. Additional research is needed with human participants before conclusions can be drawn. Astaxanthin is a powerful carotenoid with antioxidant properties, which is a natural compound that can reduce oxidative stress in the body caused by free radicals. Additionally, men treated with astaxanthin achieved higher rates of pregnancy compared with a placebo group. Click here to find out. A single-blind clinical investigation. An upper toxicity limit is not known. Chen JT, Kotani K. Astaxanthin as a potential protector of liver function: a review. Studies have demonstrated that astaxanthin is a natural antioxidant product and it is widely used in the fields of medicine, health-care products and cosmetics. It's. View abstract. Suganuma, K., Nakajima, H., Ohtsuki, M., and Imokawa, G. Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts. One animal study showed that astaxanthin significantly alleviated the oxidative stress in developing cultured follicles and ovarian cells caused by BPA administration in vivo and in vitro. Note that the numbers in parentheses (1, 2, etc.) Another review published in the journal Marine Drugssuggested that astaxanthin could protect against atherosclerosis, which is the buildup of fat and cholesterol in the arteries. Zhou X, Cao Q, Orfila C, Zhao J, Zhang L. Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing. 4-20-2011;585(8):1249-1254. 2012;59(1):43-47. Ohgami, K., Shiratori, K., Kotake, S., Nishida, T., Mizuki, N., Yazawa, K., and Ohno, S. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. . This information may not fit your specific health circumstances. Belcaro G, Cesarone MR, Cornelli U, et al. Other natural food sources of astaxanthin include shrimp, crayfish, krill, trout, yeast and algae. When used as directed, astaxanthin has actually been found to support athletic performance and recovery. In my opinion (and experience), why take the risk? Algae, salmon, yeast, trout, shrimp, krill, and crayfish are Astaxanthin's natural food sources. Cancer Lett. Astaxanthin has shown the highest oxygen radical absorbance capacity (ORAC), many magnitudes higher than other common antioxidants such as -tocopherol, -carotene, -carotene, lutein and lycopene. Antioxidant activities of astaxanthin and related carotenoids. Nutrients 2017;9(4):387. Bioorg.Med Chem 8-15-2006;14(16):5451-5458. Antioxidants are well known for providing a protective role for different immune functions. Natural Medicines: Astaxanthin. Antioxidants, including astaxanthin, have been shown to support female hormones by cleaning up oxidative stress. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study. Miki, W., Hosoda, K., Kondo, K, and Itakura, H. Astaxanthin-containing drink. Astaxanthin is a carotenoid, like beta-carotene. Both the kidney and the liver are essential for detox! But what exactly is astaxanthin? When we exercise, the body is put under stress and has to adapt. Panminerva Med 2010;52:49-54. However, more research is needed before astaxanthin can be recommended for any of these uses. For example, in one small placebo-controlled study10, individuals who took a supplement with astaxanthin for 12 weeks experienced improved memory and cognition. Here are 5 promising benefits and uses of saw palmetto. What To Consider. of fatty fish (salmon, makerel, sardines, halibut, herring) per week. Astaxanthin has been used safely by itself in doses of 4 to 40 mg daily for up to 12 weeks. View abstract. WebMD does not provide medical advice, diagnosis or treatment. Anticancer Res 1999;19:1849-54. Astaxanthin can be derived from a yeast called Phaffia rhodozyma or from a microalgae called Haematococcus pluvialis. View abstract. Initially, its best to start with a low dose and work your way up to assess your tolerance. Fortunately, several studies have found that astaxanthin can improve the health of the eyes and help maintain 20/20 vision. Another one of the benefits of astaxanthin is its demonstrated enhancement of immune health. As the leading cause of death, heart disease is a major problem around the world. 6,245,818). 2002;21(5):490. * Astaxanthin can also enter the layers of cell membranes, ultimately helping to protect the cell from oxidative stress.*. Astaxanthin is a carotenoid, a chemical found naturally in certain plants and animals. View abstract. One trial suggested that up to 6 mg per day is safe. View abstract. Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism. Most of the small research studies to date have used between 2 mg and 12mg daily. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. 2009 - 2023 MindBodyGreen LLC. Other high-antioxidant foodsthat can help relieve inflammation and ward off disease include turmeric, ginger, dark chocolate and blueberries. Yoshida H, Yanai H, Ito K, Tomono Y, et al. View abstract. 2006;10:91-95. In this study, the cyclists supplemented with 12mg per day of astaxanthin for 7 days prior to the event and experienced enhanced whole-body fat oxidation rates in the final stages of the endurance race and improved total time. 2015;54(2):301-7. People use astaxanthin for many purposes,. Despite being associated with a long list of health benefits, astaxanthin found itself at the center of controversy just over a decade ago. Into this exciting area of health benefits, astaxanthin has actually been to. A microalgae called Haematococcus pluvialis different purposes amounts of astaxanthin for 12 weeks experienced improved memory cognition., Cornelli U, et al animal study showed that astaxanthin is likely safe has! 4 to 40 mg daily for up to 12 weeks experienced improved and... 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