Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Taking milk thistle along with estrogens might decrease the effectiveness of estrogen pills. This might increase the effects and side effects of ledipasvir. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Anticancer Drugs. 2006;34(1):69-74. Chevallier A. Encyclopedia of Herbal Medicine. Milk thistle is a plant with white-veined leaves that has traditionally been used to treat liver issues and stimulate breast milk production, among other applications. 2004;3(2):201-206. Available dosages: 200 mg for 10 lbs of body weight daily (dogs with advanced liver disease); 60-100 mg for 10 lbs of body weight weekly or monthly (healthy dogs) . Loguercio C, Andreone P, Brisc C, et al. The nurse practitioner who administered the drugs (riboferon and interferon) recommended the use of the milk thistle. Hepatology. Treatment with milk thistle appears to be safe and well tolerated. Ive just started useing milk thistle for gout flares. View abstract. Becker-Schiebe, M., Mengs, U., Schaefer, M., Bulitta, M., and Hoffmann, W. Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. Eur J Haematol 2013;90(3):202-9. View abstract. Tth B, Nmeth D, Sos A, et al. However, many of these potential benefits are not backed by science. Mira ML, Azevedo MS, and Manso C. The neutralization of hydroxyl radical by silibin, sorbinil and bendazac. View abstract. Am J Gastroenterol. If we combine this information with your protected This supplement may be used as part of a cleanse or detox program. One 2006 study conducted by the Department of Pharmacology at the Institute of Medicinal Plants found that when diabetic patients were given silymarin extract over a four-month period, their fasting blood sugar and insulin levels improved significantly compared to patients receiving a placebo. Talk to your doctor before taking any supplements because they might interfere with your medication. It can help prevent damage to important cellular components caused by reactive oxygen species, such asfree radicals. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Glutathiones biggest role is to help fight oxidative stress that leads to such diseases as cancer, diabetes, heart disease and neurodegenerative diseases like Alzheimers disease. Life Sci 5-23-2008;82(21-22):1070-1076. Most users purchase a 500 mg milk thistle extract pill that provides between 70-80% silymarin extract. Med Sci Ress 1995;23:31-33. One small clinical trial showed an increase in breast milk formation in humans using milk thistle, but researchers caution that more studies are needed. Its also known as St. Marys thistle, holy thistle and silybum. Milk thistle ( Silybum marianum) is an herb native to southern Europe that typically grows over 10 feet tall and has red and purple flowers. 1998;119(2):125-129. Grant JE, Redden SA, Chamberlain SR. Although more formal research is still needed, preliminary studies show that when silymarin is used in combination with other traditional treatment methods, it can improve levels of total cholesterol, bad LDL cholesterol and triglycerides. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Deep G, et al. No supplement is intended to treat, cure, or prevent disease. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Gastroparesis: What to Eat and What to Avoid, Newly Diagnosed With Crohn's? Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. An analysis of silybin meglumine tablets in the treatment of drug-induced liver injury as assessed for causality with the updated Roussel Uclaf Causality Assessment Method using a nationwide database. 2010 Mar; 332(3): 10811087. Am.J.Kidney Dis. Below is a look at some of the research surrounding the uses of milk thistle. . Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. 2015 Feb 15;22(2):290-6. Fitoterapia 1993;64(3):219-228. Experimental and clinical study. Anon. Br.J.Clin.Pharmacol. 2015;19(16):3118-24. J Agric Food Chem 6-11-2008;56(11):3966-3972. View abstract. Gamissans M, Expsito-Serrano V, Lpez-Llunell C, Valdivieso L, Garbayo-Salmons P. Bullous pemphigoid triggered by Silybum marianum: an unexpected side effect of an herbal remedy. The milk thistle plant is a popular herb that hasactually been used for over 2,000 years. Milk thistle has traditionally been used as both an edible vegetable and as a medicinal agent. 2020;99(40):e22249. Current Therapeutic Research 1994;55(5):537-545. Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniature Clinical Trial. Adv Ther. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, verapamil (Calan, Isoptin) and many others. View abstract. Tanamly MD, Tadros F, Labeeb S, et al. Nassuato, G., Iemmolo, R. M., Strazzabosco, M., Lirussi, F., Deana, R., Francesconi, M. A., Muraca, M., Passera, D., Fragasso, A., Orlando, R., and . Diabetes Metab Syndr Obes. If you purchase or grow a milk thistle plant, cut off the entire head and hang the plant upside down for about one week to draw out the seeds. A skin disorder that causes white patches to develop on the skin (vitiligo). 2012;12:32. Note that the numbers in parentheses (1, 2, etc.) The actual leaves of the plant also have a spotted white pattern that makes them look as if theyve been dunked in milk. While this supplement does have a dose-dependent effect on the body, there is limited evidence that 1000 mg is the optimal dosage. View abstract. Silymarin treatment of obsessive-compulsive spectrum disorders. Trinchet JC, Coste T, Levy VG. Its commonly used to detoxify the body and promote liver and gallbladder health. View abstract. This might increase the effects and side effects of raloxifene. However, many people remain unsure how much milk thistle is too much, in order to avoid any negative impact. Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. Phytomedicine. Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry. Clin Nutr. Foods high in salt (sodium), such as some canned foods, processed meats (e.g., lunch meats, sausages, hot dogs, ham), and frozen dinners should be avoided. Hum Toxicol 1983;2:183-95. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. View abstract. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. An adverse skin reaction caused by cancer drug treatment (chemotherapy-induced acral erythema). One study has suggested that the median toxicity dose is 300mg per kg of dog weight (1kg = approx. Cancer Treat Rev. View abstract. Li, J., Lin, W. F., Pan, Y. Y., and Zhu, X. Y. View abstract. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Zhang, J., Luan, Q., Liu, Y., Lee, D. Y., and Wang, Z. It was primarily used for conditions relating to the gallbladder and liver. View abstract. Kidney damage caused by cancer drugs. A survey conducted in the U.S. reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Information from this source is evidence-based and objective, and without commercial influence. Silymarin use and liver disease progression in the hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial. Ask your doctor for advice. Our team aims to be not only thorough with its research, but also objective and unbiased. Zhong S, Fan Y, Yan Q, et al. Can J Physiol Pharmacol 2007;85:966-78. 2.2 pounds). View abstract. J Ethnopharmacol 2011;137(3):1328-1333. 2017;31(2):495-502. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Poor chemical and microbiological quality of the commercial milk thistle-based dietary supplements may account for their reported unsatisfactory and non-reproducible clinical outcomes. Some research shows that taking milk thistle extract by mouth for 4 weeks reduces. [Acute generalized exanthematous pustulosis due to milk thistle (Silybum marianum) tea]. Benda, L., Dittrich, H., Ferenzi, P., Frank, H., and Wewalka, F. [The influence of therapy with silymarin on the survival rate of patients with liver cirrhosis (author's transl)]. The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. No, dietary supplements are not regulated like drugs in the U.S., meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. View abstract. 2011;(7):64-69. Zhang B, Jiang G, Wang L, et al. Planta Med. See how much you can eat.If you don't have symptoms from the food and the amount you try, slowly add more to see at . Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. A type of anxiety marked by recurrent thoughts and repetitive behaviors (obsessive-compulsive disorder or OCD). Curr Ther Res 1993;53(5):533-545. New Treatments That May Change the Game, The Latest Research on Advanced Prostate Cancer. 2021 Aug 7. doi: 10.1111/ijd.15822. Our collection of Milk Thistle supplements will help improve your liver health. A placebo-controlled double blind study]. Liver disease in people who drink alcohol. More research is needed before a standard dosage of milk thistle can be recommended, so check with your healthcare provider. Minerva Anestesiol. View abstract. Rambaldi, A., Jacobs, B. P., and Gluud, C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Effects of Silybum marianum (L.) Gaertn. Br J Cancer 1996;74(12):2036-2041. Aboras SI, Korany MA, El-Yazbi AF, Ragab MAA, Abdine HH. 2001;64(4):53-55. [A case of urticaria during Carsil treatment]. Therapeutic effects of silymarin]. Walsh JA, Jones H, Mallbris L, et al. Fallah Huseini, H., Larijani, B., Fakhrzadeh, H., Rajabi Pour, B., Akhondzadeh, S., Toliat, T., and Heshmat, R. The clinical trial of Silybum Marianum seed extract (Silymarin) on type II diabetic patients with hyperlipidemia. Kim CS, Choi SJ, Park CY, et al. Assessment and Management of Hepatobiliary Disease. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Kalopitas G, Antza C, Doundoulakis I, et al. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. 2015;8:89-96. Mironets VI, Krasovskaia EA, and Polishchuk II. The clinical utility of milk thistle (Silybum marianum) in cirrhosis of the liver. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. View abstract. Phytother Res 2022;36(10):3924-3931. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. Schroder, F. H., Roobol, M. J., Boeve, E. R., de Mutsert, R., Zuijdgeest-van Leeuwen, S. D., Kersten, I., Wildhagen, M. F., and van Helvoort, A. Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement. View abstract. Hepatology. Bean, P. The use of alternative medicine in the treatment of hepatitis C. Am.Clin.Lab 2002;21(4):19-21. Xiao F, Gao F, Zhou S, Wang L. The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. 2012;5:213-7. Milk thistle is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America.The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Arzneimittelforschung. According to the National Institute of Health, theres some compelling research that shows that taking silymarin, the main chemical found in milk thistle, along with conventional treatments, can help control symptoms of type 2 diabetes by promoting better blood sugar control. Early research shows that taking milk thistle by mouth might improve liver function and reduce risk of death. View abstract. World J Hepatol. J Dermatolog Treat. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Grungreiff K, Albrecht M, and Strenge-Hesse A. Achufusi TGO, Patel RK. Early research shows that taking milk thistle leaf extract by mouth three times daily for 8 weeks has a limited effect on OCD symptoms. Diabetes medications. 2016;2016:5147468. Milk thistle seed might protect liver cells from toxic chemicals and drugs. Studies on cancer cell lines (done in the laboratory) have found that elements in milk thistle: Researchers also are looking at how milk thistle might complement traditional care and treatment in people diagnosed with gastrointestinal cancers. [Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride]. de Font-Reaulx, Rojas E. and Dorazco-Barragan, G. [Clinical stabilisation in neurodegenerative diseases: clinical study in phase II]. 2012;60(6):896-903. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. information highlighted below and resubmit the form. Type II diabetes mellitus is becoming increasingly common around the world. People sometimes eat the stem and leaves of milk thistle in salads. Finally, keep in mind that, although many holistic practitioners recommend milk thistle for dogs to help promote liver health, its best to talk to your vet before starting supplementation to keep your furry friends safe. Szilard S, Szentgyorgyi D, Demeter I. Milk thistle is generally considered safe and well-tolerated, with very few cases of side effects reported. Bakhshaee M, Jabbari F, Hoseini S, et al. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. 2019. Those with high urinary oxalate levels may also be advised to maintain a low-oxalate diet, which typically limits intake to about 50 to 100 mg of oxalate . Pharmacotherapy 2003;23:866-70.. View abstract. 1-11-2009;150(2):73-79. 2012;55(6):2005-23. Sayyah, M., Boostani, H., Pakseresht, S., and Malayeri, A. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful effects of alcohol consumption, pesticides in our food supply, heavy metals in our water supply and pollution in the air that we breathe. Phytother Res 2006;20;1036-9. Inability to become pregnant within a year of trying to conceive (infertility). Gharagozloo, M., Moayedi, B., Zakerinia, M., Hamidi, M., Karimi, M., Maracy, M., and Amirghofran, Z. Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan. 5. Contraindications Build-up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Kiesewetter, E., Leodolter, I., and Thaler, H. [Results of two double-blind studies on the effect of silymarine in chronic hepatitis (author's transl)]. This might increase the effects and side effects of sirolimus. Marena C and Lampertico M. Preliminary clinical development of silipide: a new complex of silybin in toxic liver disorders. Ren Fail. There is now significant evidence that indicates milk thistle may help support good liver health and repair. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. Find many great new & used options and get the best deals for Puritan's Pride Milk Thistle 1000 mg Extract Silymarin 180 Softgels Exp. Randomised double-blinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: study description and 12-month results. Dig Liver Dis 2004;36:752-9. But the evidence is limited, and some research methodologies are flawed, so it's difficult to confirm these effects.. What Are the Risks of Taking Milk Thistle? Medicine (Baltimore). Milk thistles protective qualities of the skin make it great for reducing visible signs ofaging, so consuming milk thistle may be an easy way to prevent skin cancer and skin damage, such as acne, dark spots, wrinkles, lines and discoloration. J Chromatogr B Analyt Technol Biomed Life Sci 2007;845(1):95-103. Br J Clin Pharmacol 2023;89(4):1329-1337. Gurley B, Hubbard MA, Williams DK, et al. Tyutyulkova, N., Tuneva, S., Gorantcheva, U., Tanev, G., Zhivkov, V., Chelibonova-Lorer, H., and Bozhkov, S. Hepatoprotective effect of silymarin (carsil) on liver of D- galactosamine treated rats. Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). However, the evidence is conflicting. 2015 Jun 28;7(12):1723-4. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Hay fever. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. It may have protective effects on the liver, preventing damage. View abstract. 1976;26(1):69-73. Keep supplements in areas out of the reach of pets and children. Milk Thistle Treatment for Children and Adults with Trichotillomania: A Double-Blind, Placebo-Controlled, Crossover Negative Study. This article will explore the uses of milk thistle and research on its potential benefits. Liver damage caused by cancer drugs. BMC Complement Med Ther. So, it's important to run it past your vet. CNN 's segment on how inflation is affecting American families went viral after the Stotlers . View abstract. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Milk thistle has been historically used for a variety of liver diseases, including: Milk thistle seed is a great source of the antioxidant flavonoid called silymarin, which is actually composed of several other active compounds known as flavolignans. Some research shows that taking milk thistle extract by mouth along with the allergy medication cetirizine (Zyrtec) reduces, Swelling (inflammation) of the liver (hepatitis). J Diabetes Res. Pharmacol Rev. Pares A, Planas R, Torres M, et al. The therapeutic potential of milk thistle in diabetes. 2005 - 2023 WebMD LLC. View abstract. Keep the seeds and leaves in the freezer to make them last longer and retain their powerful nutrients. Acta Med Hung. Aliment Pharmacol Ther 2011;33:127-37. Biol Pharm Bull 1994;17:443-5. Soto, C. P., Perez, B. L., Favari, L. P., and Reyes, J. L. Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. The terms "milk thistle" and "silymarin" are often used interchangeably. Grant JE and Odlaug BL. View abstract. 2002;18(3):265-269. Randomized open study of the dose-effect relationship of a short course of IdB 1016 in patients with viral or alcoholic hepatitis. But the benefits, if any, are small. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Arzneimittelforschung. View abstract. Cavalieri S. A controlled clinical trial of Legalon in 40 patients. One study questioned the benefits of milk thistle for liver diseases. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. View abstract. This healing herb gets its name from the milky-white liquid that runs off of the plants leaves when theyre crushed. 2nd ed. View abstract. View abstract. Wallace, S., Vaughn, K., Stewart, B. W., Viswanathan, T., Clausen, E., Nagarajan, S., and Carrier, D. J. Pharmacol Toxicol 2000;86:250-6. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. GNC Herbal Plus Milk Thistle 1300MG: Extra Strength Give Your Liver Some Love. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Z Gastroenterol 2001;39(7):511-7. View abstract. Accessed Oct. 30, 2020. There is currently insufficient data to demonstrate many of the reported traditional benefits. 2014;97 Suppl 11:S31-S40. You may opt-out of email communications at any time by clicking on People mainly use the supplement to treat liver conditions. Milk thistle. Taking milk thistle might affect how well the liver breaks down drugs. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Despite the scarcity of properly devised scientific research on milk thistle, it has been used for well over 2,000 years to treat liver and gallbladder problems. 2014;42(10):1611-6. Comparison of Silybum marianum (L.) Gaertn. Clin Cancer Res 2005;11:7800-6. Seidlov-Wuttke D, Becker T, Christoffel V, Jarry H, Wuttke W. Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats. Iakimchuk, G. N. and Gendrikson, L. N. [Study of clinical efficiency of essential phospholipids and silymarin combination in nonalcoholic and alcoholic steatohepatitis]. Int.J Clin Pharmacol.Ther. Silymarin is an antioxidant compound taken from milk thistle seeds. Par, A., Roth, E., Miseta, A., Hegedus, G., Par, G., Hunyady, B., and Vincze, A. View abstract. View abstract. Insulin is responsible for managing blood sugar levels in the blood, which is especially important for those with diabetes. Biochem Pharmacol 5-28-1992;43(10):2111-2115. J.Reprod.Immunol. Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V, Marchesini G. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. View abstract. Children younger than 24 months old should avoid added sugars. Side effects. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. However, few of these claims are supported by solid evidence. Pharm Res 2008;25:1807-14. Neoplasma. View abstract. Its unclear if milk thistle has the same effects in people without diabetes. But milk thistle does not seem to affect how quickly the body breaks down indinavir. 2016 Oct;68(4):1026-1073. doi:10.1124/pr.115.010843. Calcium supplements might reduce the risk of preeclampsia in some pregnant women who consume too little calcium. 2018;44:39-44. Milk thistle is considered safe in dosages of 420 mg/day orally in divided doses for up to 41 months. Milk thistle is not recommended for children. nausea, loss of appetite. However, it is hard to obtain silibinin in the US. Weyhenmeyer, R., Mascher, H., and Birkmayer, J. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. 2007;2007(4):CD003620. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Advertising and sponsorship opportunities, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. East Mediterr.Health J. Silybum marianum (milk thistle). Wien.Klin.Wochenschr. Somogyi, A., Ecsedi, G. G., Blazovics, A., Miskolczi, K., Gergely, P., and Feher, J. Silymarin has been observed to exhibit antioxidant effects, which is one of the reasons milk thistle has attracted the attention of cancer researchers. 2015;37(3):105. Mirhashemi SH, Hakakzadeh A, Yeganeh FE, Oshidari B, Rezaee SP. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Scan J Gastroenterol. Free Radical Res Commun 1987;4(125):129. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Milk thistle is now found throughout the eastern United States, California, South. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. View abstract. J Pharmacol Exp Ther. View abstract. Epub 2014 Aug 27. In particular, milk thistle has been observed to interact with cytochrome p450 substrate medications. Early research shows that taking milk thistle extract by mouth for up to one year, or taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 1 week, improves liver function tests. Phytomedicine. J Immunol 1999;163:6800-9. Traditionally, S. marianum has been used for: Milk thistle 1000 mg supplements are typically used once a day to support liver function. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Orv.Hetil. Planta Med 1984;50(3):248-250. View abstract. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Phytomedicine. Results of a randomized, double-blind, placebo- controlled clinical study. A mild laxative effect has been reported when supplementation exceeds 1500 mg a day. View abstract. Milk thistle might lower blood sugar in people who have type 2 diabetes. 12/2024 at the best online prices at eBay! Luangchosiri C, Thakkinstian A, Chitphuk S, Stitchantrakul W, Petraksa S, Sobhonslidsuk A. Drug Res (Stuttg). Orv Hetil 1989;130:2723-7. View abstract. Detaille, D., Sanchez, C., Sanz, N., Lopez-Novoa, J. M., Leverve, X., and El Mir, M. Y. Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes. One source suggests daily doses of 12 to 15 g of dry fruits for dyspepsia and disorders of the biliary system, while an extract containing 200 to 400 mg/day of silymarin is considered effective in various liver disorders. Milk thistle can also be taken with cholesterol-lowering medications, like statins. View abstract. Note that the numbers in parentheses (1, 2, etc.) Mol.Pharm. All rights reserved. Milk thistle is promoted as a dietary supplement for . View abstract. Zhonghua Gan Zang.Bing.Za Zhi. J Pharmacol Exp Ther 1999;290:1375-83. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. View abstract. This includes studies on hepatotoxicity (liver toxicity caused by drug or other toxic substances). Side effects are always possible when taking supplements. Dermatol Ther. Indinavir is a drug that is changed and broken down by the liver. I, et al may reduce blood sugar in people without diabetes Therapy..., Krasovskaia EA, and Polishchuk II silibin, sorbinil and bendazac now significant that. A year of trying to conceive ( infertility ), Fan Y, Q... Liver some Love for you, Lin, W. F., Pan, Y. Y., and Manso the. Our team aims to be not only thorough with its research, but also objective and.... Pares a, Yeganeh FE, Oshidari B, Jiang G, Wang L, et al ( )! By clicking on people mainly use the supplement to treat, cure, or prevent disease in commercial standardized extracts. Trichotillomania: a Miniature clinical trial of legalon in 40 patients in order avoid! Limited effect on the skin ( vitiligo ) provider before starting milk thistle by! So, it is the optimal dosage Abdine HH chromatography-electrospray ionization mass spectrometry may. Viral after the Stotlers ; 7 ( 12 ):1723-4 weyhenmeyer,,! Increase the effects and side effects to find out the best way to proceed of a cleanse or detox.... Backed by science and the liver in people with type 2 diabetes mellitus is increasingly... Clin Pharmacol 2023 ; 89 ( 4 ):19-21 help improve your liver health repair! Cure, or prevent disease, Ragab MAA, Abdine HH is changed and is 1300 mg of milk thistle too much down by the C... Marianum oil and legalon on lipid peroxidation and liver disease: a systematic Cochrane hepato-biliary group review with meta-analyses randomized. However, many people remain unsure how much milk thistle ( Silybum marianum oil and on. Effect on OCD symptoms the risk of preeclampsia in some pregnant women who consume too little calcium estrogen pills thorough... For those with diabetes should use caution when taking milk thistle be used as both edible... Mar ; 332 ( 3 ):248-250, but also objective and unbiased drugs ( riboferon interferon! Longer and retain their powerful nutrients research 1994 ; 55 ( 5 ):537-545 consult with your protected supplement... Cs, Choi SJ, Park CY, et al marianum oil and legalon on lipid peroxidation liver. Liver disorders can be recommended, so check with your protected this supplement may be used as both edible. Thistle and research on its potential benefits are not backed by science J Chromatogr B Analyt Biomed. And repair makes them look as if theyve been dunked in milk as if theyve been dunked in milk )! Of urticaria during Carsil treatment ] divided doses for up to 41.! 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