My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) Appreciated!!! ? (Many products dont repel insects, and if they do are often very strong chemical formulations.). If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. My plan is to adopt a senior Border to go with my lazy Roughs. Thanks. Leaders in MDR1 testing since 2004. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Thanks much for the info before I bought anything! It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. I had never heard of Dimmitrol before, but I did some research after reading your comment. Plus, Simparica's protection lasts for five weeks (35 days), and it does not decrease at the end of the month. Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. Im just looking for advice as to tick prevention medication. The author states this had no connection to the drug study. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. In summary, use with caution. Is hartz ultraguard ear mite treatment for dogs safe? The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. I have been told that Advocate is safe for him at the recommended dose. Selamectin is their shared main ingredient. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. On the downside, its efficacy only lasts for about a day. I have a new Collie-mix with bi-coloured coat. You can even scatter some on your dogs bed. Unfortunately, the fleas are fighting back. Two years ago he tested positive for lyme disease and was treated with antibiotics. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Pills or chews that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said Thursday. Please let me know how the Wondercide works for you! (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). Is Simparica Safe for Dogs? I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. My Vet told me Trifexis was safe to give them. Safe for dogs from 1.25 kg; Can be given with our without food; Pork liver flavoured chewable tablet; Safe in heartworm positive dogs; Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Heartworm. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. (Which made him feel really sick.) The most common side effect of Simparica is vomiting, which can happen within the first hour or two after administration. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Thank you thank you thank you for this article. I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Each tablet is formulated to provide minimum dosages of 1.2 mg/kg sarolaner, 24 g/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Thank you. We actually live in New Hampshire and hike (off-leash) quite frequently. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! Should I give them Trifexis or Sentinel Spectrum? Our team of veterinary pharmacologists provide a current list of medications documented to cause adverse reactions or are strongly suspected to cause adverse reactions in dogs with the MDR1 mutation. Both spot ons and both effective in that neither of . And its possible for dogs and humans both to have allergies even to natural essential oils. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. (MDR1 -/-) following single oral administration at 5 times the . I just picked out a beautiful tri color rough collie this morning! Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. A similar medication, Comfortis (spinosad), only treats external parasites. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. They said Frontline Plus doesnt really work anymore like it used too. She was obviously in discomfort. I grew up in Michigan, and we always discontinued pest products during the cold season. new post updates in monthly email newsletters. Thanks. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . Thank you very much! Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. We do eat it! Up until last month, it was always advocate through winter and advantix through summer tick season. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient My dog has been tested and is mutant/normal (MDR1). As more dogs are tested, more breeds will probably be added to the list of affected breeds. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. Hi Debbie! Later, the vet had the experience of this happening to other cats and one of his own. The safe use of SIMPARICA has not been evaluated in breeding, pregnant, or lactating dogs. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. I went back to using Frontline Plus for them. Sarolaner is also used in combination products for both dogs and cats. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. I did not need to try the Seresto collar. For years she was taking Sentinel for both heart-worm and tick prevention. For dogs and cats with the MDR1 mutation, common medications can be potentially deadly. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). Im trying to find out if this is safe for her. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Wow! ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. I am going to try WonderCide as recommended by my Vet for fleas. SIMPARICA was administered in a well-controlled US field study, which included a total of 479 dogs (315 dogs treated with SIMPARICA and 164 dogs treated with active control once monthly for three treatments). But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. This May he tested positive again, but the vet thinks it could be residual from when he had it before. He was getting quite stiff and sore, but he acts like a much younger dog now. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. Thank you for the research and the detailed info on each product. Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. I have no experience with ivermectin and fleas/ticks, but it would be worth a try, assuming you have the right form and dose. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Fleas this summer in my part of CA are particularly bad. Freckles my Aussie/Pyr is such a great dog. What Can Cause Seizures in Dogs? My Aussie/Pyrenees mix has had no issues with it, for instance. Best of luck with your new girl! He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. This can be orally administered to the dogs, which are safe and remain effective for one full month. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? This paper detailed a study done using 16 collies, eight males and 8 females. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Its worth making a phone call to see what they would recommend for your pup. After logging in you can close it and return to this page. I do remember her cowering and rubbing her back against her crate after we administered anything topical! She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! The best thing about Seresto is how long it can do its job up to 8 months! Heartgard got a bad rap after too many dogs had negative reactions to the medication. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. It was both well written, and concise. Flea allergy dermatitis tends to occur mostly in the late summer. Would this be your recommendation? Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. I read that you you used this combination with success. 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