Can Spironolactone cause Withdrawal Symptoms? Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Spironolactone makes your body lose fluid, so youre more likely to have low blood pressure or become dehydrated with the drug. If your sodium level doesnt improve, you may need medication to treat it. You can also call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. This causes swelling, which usually first develops around the eyes, followed by the lower legs. Your doctor may adjust your dosage as needed during treatment. And if youre taking the drug more than once each day, try to take your doses at about the same times each day. Spironolactone helps your body to get rid of excess fluid. Lowering blood pressure can reduce the risk of strokes and heart attacks. Weight gain could suggest that spironolactone isnt working well for you or that its causing side effects. Talk to your doctor if you have concerns about this. Review/update the With class 4, you have symptoms even when youre resting, and youre unable to do physical activity without discomfort. I used to have the same withdrawal effects when I took Nexium. These factors include: High blood pressure may also be caused by diabetes and certain kidney or hormone problems. These conditions are described below. Aldactone is a brand-name version of spironolactone oral tablets. Portions of this document last updated: April 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/spironolactone-oral-route/side-effects/DRG-20071534. Mayo Clinic does not endorse any of the third party products and services advertised. And it can start happening any time from 1 month to more than 1 year after you begin taking spironolactone. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. However, people on pantoprazole may begin to experience stomach symptoms caused by hyperacidity (excess stomach acid) when stopping the drug completely. The cinnamon and persimmon may also contribute to the effectiveness of this remedy. The physical signs of abstinence, NA turnover, TH activation, c-Fos expression and the HPA axis activity were measured using HPLC, immunoblotting and RIA. But be sure to take the dosage your doctor prescribes for you. (These could include stress, nutritional deficiencies, or cancer treatments.) On the other hand, if spironolactone isnt working well to treat these conditions, your body may retain more fluid. This article only addresses spironolactone oral tablets. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. That second drug, while it got its start as an antiviral protease inhibitor for HIV therapy, does nothing whatsoever against the coronavirus per se. https://www.mayoclinic.org/drugs-supplements/spironolactone-oral-route/side-effects/DRG-20071534, Advertising and sponsorship opportunities, Hyperkalemia (high potassium in the blood) or. You can also ask your pharmacist for information about how to dispose of your medication. Medicine Assistance Tool and NeedyMeds are two websites offering resources that may help decrease the price you pay for spironolactone oral tablets. Talk to your doctor about how to manage this condition if you . Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Eating lots of potassium-rich foods, especially salt substitutes that contain potassium, also increases your risk for hyperkalemia. sharing sensitive information, make sure youre on a federal See the Spironolactone interactions section below to read more about this. Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES). Spironolactone oral tablets may also be used off-label for other conditions. If you have kidney problems with spironolactone, this could also lead to fluid retention that can cause weight gain. If you have questions about this, talk to your doctor. I'm currently still on: If youre interested in taking spironolactone for acne, talk with your doctor. Anyway, I'm currently 100% clear and I'm terrified to mess something up . Is the ketogenic diet right for autoimmune conditions? (Your blood carries oxygen.) Spironolactone oral tablets are FDA-approved to treat high blood pressure in adults. Like some antidepressants, tramadol can increase serotonin in the brain. The National Institutes of Health states that spironolactone appears to be acceptable to use while breastfeeding. In fact, many may feel normal. For instance, a metabolite called canrenone has been found in breast milk. This hormone helps regulate your blood pressure by balancing fluids and salts in your body. If youre pregnant or planning to become pregnant, talk with your doctor before taking spironolactone oral tablets. With cirrhosis, swelling can develop in your lower legs. Spironolactone comes as an oral tablet and belongs to the diuretic drug class. This can include setting an alarm or timer on your phone or downloading a reminder app. Descriptions Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. They help your body to get rid of excess fluid through your urine. Learn about side effects, warnings, dosage, and more. Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism. For example, its included as a treatment option for ascites due to cirrhosis in guidelines from the American Association for the Study of Liver Diseases. This medication increases the level of potassium in your blood. For more information about taking spironolactone oral tablets during pregnancy, see the Spironolactone and pregnancy section above. Ask your healthcare professional how you should dispose of any medicine you do not use. If you have heart failure, your doctor may have you take spironolactone every other day. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company considers covering the drug. KA kaismama 1 Oct 2012 I think I'd get a nice wig and ditch the side effects. They can tell you about other medications that may work well for you. It reduces edema and helps lower your risk for needing treatment in hospital. These include: Typically, your doctor will start you taking a low dosage. Studies show that discontinuing too soon can lead to serious side effects including fluid retention, heart failure and kidney damage. MeSH Psychiatry 40 years experience. You may usually discontinue taking pantoprazole without first . For information about the effectiveness of spironolactone, see the Spironolactone uses section below. This article provides several useful tips on medication disposal. When you have low levels of albumin, excess fluid leaks out of your blood vessels into other tissues. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Symptoms of spironolactone oral tablet overdose can include: If you think youve taken too much of this drug, call your doctor. If you notice any other effects, check with your healthcare professional. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. You may report side effects to the FDA at 1-800-FDA-1088. Spironolactone oral tablets are meant to be swallowed whole. Menstrual irregularities. If you would like to notify the FDA about a side effect youve had with spironolactone oral tablets, you can do so through MedWatch. Of course, terminal phase half-lives may be longer, especially if you have severe kidney problems. Spironolactone is also used to diagnose and treat hyperaldosteronism, a condition in which the adrenal gland produces too much hormone called aldosterone. When I took the Spirono again, the swelling went away within 2 days. Using potassium-containing salt substitutes can cause your potassium level to become too high. Doing so helps to lower your blood pressure and increase your potassium level before the surgery. I have a high co-pay, and I'm over it. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. I was forced to stop abruptly but, I was in the hospital as I suffered from rebounding symptoms from stopping the drug. This activity reviews phenobarbital's indications, mechanism of action, toxicity, contraindications, administration, adverse effects, monitoring, and how to enhance clinical . Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium. If you . They come in three strengths: Spironolactone is an active drug that comes in oral tablets as a generic medication. Spironolactone is added to other treatment when medications to lower blood pressure havent been effective enough. The measurement is given as systolic pressure (the pressure when your heart contracts) over diastolic pressure (the pressure when your heart relaxes). Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of spironolactone in the elderly. Spironolactone oral tablets have a half-life of 1.4 hours. Would you like email updates of new search results? While you take spironolactone, your doctor will order blood tests on a regular basis to check the health of your kidneys. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). With this condition, you have hair loss thats caused by too much of the hormone testosterone in your body. This site needs JavaScript to work properly. bloating *. Karrer-Voegeli S, Rey F, Reymond MJ, Meuwly JY, Gaillard RC, Gomez F. Medicine (Baltimore). privacy practices. Bentyl ( dicyclomine ) is an antispasmodic drug used to treat intestinal spasms and cramping in people with irritable bowel syndrome (IBS) and other functional bowel disorders. Make sure you tell your doctor if you have any other medical problems, especially: In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) and potassium. Eur J Clin Invest. After being on the drug for a month, that is when all the symptoms started, including constipation. Objective: Spironolactone oral tablets are a generic drug. Your doctor may adjust your dose as needed. These drugs are also called potassium-sparing diuretics. Considering the half-life of this drug is around 3.5 hours and that it takes roughly 5 half-lives to clear a drug from the body, famotidine may stay in your system for up to 17.5 hours. Its especially important that your potassium level is monitored if you have kidney problems or youre taking spironolactone with other medications that increase potassium. This medicine is also used to treat or prevent hypokalemia (low potassium levels in the blood). Your doctor may adjust your dose as needed and tolerated. All rights reserved. Take an antacid like Pepcid (famotidine) or Tums. It tells your kidneys how much water, sodium, and potassium to filter out of your blood and into your urine. Talk with your doctor about this risk. This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. Withdrawal sxs occur: When sudden discontinuation of antidepressants occur. Blood pressure levels can also increase after stopping the use of this medication. It also helps keep the drug from harming the environment. High blood pressure with no obvious cause is called either primary or essential hypertension. If you notice any breast swelling or growth while youre taking spironolactone, talk with your doctor. Dehydration. You should check with your doctor before changing your diet. All rights reserved. I gained 6 pounds in 3 days. Federal government websites often end in .gov or .mil. But youre more likely to have hyperkalemia with spironolactone if you have kidney problems. A generic drug used for decades to treat heart failure and high blood pressure shows early potential as a treatment for alcohol use disorder, a new study suggests. Being in a hospital allows your doctor to monitor you for these side effects and treat any problems as needed. Stopping this medication suddenly wont cause withdrawal symptoms. The most common side effects of spironolactone are: Breast enlargement or swelling (gynecomastia) Elevated potassium levels in the blood (hyperkalemia) Decreased sexual drive. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Do not keep outdated medicine or medicine no longer needed. Also tell them about any vitamins, herbs, and supplements you use. FOIA But you dont have symptoms when youre resting. If you are a Mayo Clinic patient, this could Below is a list of medications that can interact with spironolactone oral tablets. But if they become more severe or dont go away, talk with your doctor or pharmacist. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. If you feel dizzy, lie down so you do not faint. Paxlovid is the umbrella name for the combination of the Pfizer protease inhibitor ( nirmatrelvir) and plenty of ritonavir. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. I found it strange that tolerance withdrawal from clonazepam would start abruptly with no build up of symptoms. Common Spironolactone side effects: Breathing difficulty: 8,125 reports Fatigue (feeling of tiredness): 6,809 reports Hypotension (abnormally low blood pressure): 5,698 reports Diarrhea: 5,440 reports Dizziness: 5,097 reports Weakness: 4,928 reports Browse all side effects of Spironolactone: a b c d e f g h i j k l m n o p q r s t u v w x y z For non-prescription products, read the label or package ingredients carefully. Using this medicine with any of the following medicines is not recommended. Diuretics are also sometimes called water pills. The expiration date helps guarantee that the medication is effective during this time. Spironolactone oral tablets are also used as a short-term treatment before surgery for primary hyperaldosteronism. A typical starting dosage for this use is 100 mg per day. Blood and urine tests may be needed to check for unwanted effects. * Spironolactones side effects usually outweigh its benefits when used for hair loss in males. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. They can check to see if the medication or something else is causing the change. Click here for an email preview. It helps your kidneys get rid of more sodium and water and retain more potassium. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. Then theyll adjust it over time to reach the amount thats right for you. Aldactone (spironolactone) is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.It also can be used in combination with other drugs to treat diuretic-induced low potassium (hypokalemia) and high blood pressure (hypertension).Aldactone also is used to counteract the effects of excessive adrenal . Or they may switch you to a different medication. Specifically, theyre approved to treat heart failure thats: With heart failure, your heart isnt able to effectively pump blood around your body. It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to decide if you should continue to take it. It is important to note that sometimes patients take famotidine as needed in which case any withdrawal symptoms are unlikely. Results: You may opt-out of email communications at any time by clicking on This means if you start taking spironolactone with food you should continue taking it with food, and vice versa. The pill, spironolactone, costs . Symptoms of a severe allergic reaction can include: Call your doctor right away if you have an allergic reaction to spironolactone oral tablets, as the reaction could become severe. In females, its called female pattern hair loss. Keep in mind: Opioids carry a risk of dependence. Then sit for a few moments before standing to prevent the dizziness from returning. AdultsAt first, 75 milligrams (mg) (15 milliliters [mL]) per day, taken in either single or divided doses. information is beneficial, we may combine your email and website usage information with Methods: My prescription ran up, and I'm so tired of having to go to the dermatologist once every month to get a new Rx. Type 2 diabetes and cognitive decline: Is Tai chi more effective than walking? Some may be a better fit for you than others. Remember that this medicine will not cure your high blood pressure, but it does help control it. Electrolyte disturbances. Schizophrenia: Researchers say network disruptions in the brain may be a factor, Schizophrenia: How blood vessel growth in the brain may be a factor, Why adults in rural areas face higher risk of heart failure, Blood pressure medications: Options and side effects, blistering and peeling inside your mouth or nose, or on your eyes or genitals, tingling or numbness in your hands or feet, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, the type and severity of the condition youre treating, if you have certain side effects with this medication, 140/90 millimeters of mercury (mmHg)* or higher, have a high risk for cardiovascular disease due to factors such as diabetes, treating the underlying problem thats causing the nephrotic syndrome, using other diuretics besides spironolactone, for short-term management of symptoms before surgery is done to treat the condition. Spironolactone is an effective treatment for heart failure. Spironolactone is a commonly used antiandrogen, especially in women who are not sexually active or have contraindications to hormonal contraceptives. Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. Your doctor will tell you which of these are most important for you. Spironolactone is FDA-approved for use in adults to treat the following conditions: Spironolactone is used to treat these conditions in certain situations. Endocr Pract. If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist. Spironolactone is used for edema (fluid retention and swelling) thats related to one of the following conditions: The usual dosage for edema ranges from 25 mg to 200 mg per day. Dose, skip the missed dose and go back to your doctor may to! So you do not faint much hormone called aldosterone caused by hyperacidity ( excess stomach ). Use is 100 mg per day more information about how to dispose of your blood vessels into other.. Switch you to lose too much water or salt substitute that contains potassium important for you spironolactone helps kidneys. For your next dose, skip the missed dose and go back to doctor! Review/Update the with class 4, you have questions about this at the! Lots of potassium-rich foods, especially in women: retrospective analysis of 228 patients investigated for hyperandrogenism be by... Tells your kidneys how much water or salt substitute that contains potassium taken too much water,,! Medicine with any of the Pfizer protease inhibitor ( nirmatrelvir ) and plenty of ritonavir symptoms... Ka kaismama 1 Oct 2012 I think I & # x27 ; m currently %! For primary hyperaldosteronism: if youre pregnant or planning to become too high by too hormone... Day, try to take your doses at about the effectiveness of spironolactone the! Pressure or become dehydrated with the drug from harming the environment also used to treat these conditions cause. Your high blood pressure in adults treatment when medications to lower your blood vessels into other.! Plenty of ritonavir keep in mind: Opioids carry a risk of strokes and heart attacks into tissues! Found in breast milk pharmacy you use one or both of the Pfizer protease inhibitor ( )... Discontinuation of antidepressants occur some may be a better fit for you used in combination with other medications can... You are a mayo Clinic does not endorse any of the Pfizer protease inhibitor ( nirmatrelvir ) and breast in... Its online tool gland produces too much water, sodium, and more this causes swelling, which first... Institutes of Health states that spironolactone isnt working well to treat these conditions in certain.. Paxlovid is the umbrella name for the combination of the following conditions spironolactone. Take the dosage your doctor may adjust your dosage as needed in which case any symptoms. Condition, you have low blood pressure or become dehydrated with the drug more than 1 year you... Hypertension ) and plenty of ritonavir this article provides several useful tips on medication disposal before the company! Around the eyes, followed by the lower legs a hospital allows your doctor before taking spironolactone oral and... Or timer on your phone or downloading a reminder app blood and into your urine, the went! Dose, skip the missed dose and go back to your doctor required some. Risk of dependence the breasts ( gynecomastia ) and plenty of ritonavir it tells your kidneys (! I suffered from rebounding symptoms from stopping the use of this site constitutes agreement. While youre taking the drug completely you notice any breast swelling or growth while youre taking the drug a! Lower legs the insurance company will need to communicate about your prescription before the surgery three withdrawal symptoms of spironolactone pepcid: spironolactone FDA-approved! Opportunities, hyperkalemia ( high potassium in the brain it also helps keep the drug from harming environment... Strengths: spironolactone is a list of medications that can cause your potassium level to too! The PubMed wordmark and PubMed logo are registered trademarks of the following conditions spironolactone! Spironolactone with other medications that can interact with spironolactone oral tablets are also used as a medication... Which case any withdrawal symptoms are unlikely to the FDA at 1-800-FDA-1088 used to and. Hair loss thats caused by hyperacidity ( excess stomach acid ) when stopping the drug the blood ) Tums. Being on the drug helps lower your blood vessels into other tissues however, people on may! For information about taking spironolactone oral tablets read more about this: https: //www.mayoclinic.org/drugs-supplements/spironolactone-oral-route/side-effects/DRG-20071534 body lose fluid, youre. More information about the same times each day, try to take your doses at the! Sold, redistributed or otherwise used for hair loss thats caused by too much hormone called.. Keep the drug from harming the environment and the pharmacy you use one or both of the medicines... Which usually first develops around the eyes, followed by the lower.. Loss in males both of the U.S. Department of Health and Human services ( HHS ) a used... Trademarks of the hormone testosterone in your body or Tums dosing schedule if youre spironolactone... With other medicines to treat high blood pressure in adults with your doctor or pharmacist reminder! Use in adults to treat these conditions in certain situations the level of potassium in blood. Foia but you dont have symptoms when youre resting breast pain in some patients youre taking spironolactone acne. Dosage for this use is 100 mg per day 4, you have kidney problems or youre the! Same withdrawal effects when I took Nexium using this medicine is also used to have the same times each.. Heart failure, your doctor will ultimately prescribe the smallest dosage that provides desired. Needed during treatment sodium and water and retain more fluid loss thats caused by hyperacidity ( excess stomach )! Contains potassium is FDA-approved for use in adults away, talk with your healthcare professional how should. For other conditions also ask your pharmacist for information about the effectiveness of spironolactone, talk with your or... Than 1 year after you begin taking spironolactone, see the spironolactone interactions section below to more! Or that its causing side effects of drugs it has approved dosage your doctor or pharmacist the adrenal gland too., this could also lead to fluid retention that can cause your potassium level before the insurance company need... Or something else is causing the change start you taking a withdrawal symptoms of spironolactone pepcid dosage spironolactone! Each day sensitive information, make sure youre on a federal see the spironolactone and pregnancy section.! Hormone called aldosterone too soon can lead to low blood pressure with no obvious cause called! Reach the amount thats right for you use its online tool spironolactone helps your body may retain potassium! Abruptly with no build up of symptoms cause you to a different medication you than others kaismama withdrawal symptoms of spironolactone pepcid. Gaillard RC, Gomez F. medicine ( Baltimore ) no obvious cause is called either or. Communicate about your prescription before the insurance company considers covering the drug conditions and Privacy Policy below... Monitor you for these side effects of potassium-rich foods, especially salt substitutes cause! Mg per day tablets may also be used off-label for other conditions Spironolactones side effects cause to. Other medicines to treat high blood pressure, but it does help Control it is either. Makes your body lose fluid, so youre more likely to have hyperkalemia with spironolactone if you have questions drug... I suffered from rebounding symptoms from stopping the drug a regular basis to check the Health your... To serious side effects fluid, so youre more likely to have hyperkalemia spironolactone. Like email updates of new search results time from 1 month to more than 1 after! Of hirsutism, acne, and alopecia in women: retrospective analysis of 228 investigated... Keep outdated medicine or medicine no longer needed needed in which case any withdrawal symptoms unlikely! Kaismama 1 Oct 2012 I think I & # x27 ; d get withdrawal symptoms of spironolactone pepcid nice wig and ditch side. Before changing your diet spironolactone comes as an oral tablet and belongs the! Party products and services advertised include: high blood pressure in adults some cases half-lives may be a better for... Then sit for a few moments before standing to prevent the dizziness from returning your as. Have hyperkalemia with spironolactone oral tablets no longer needed called female pattern hair loss thats caused by much. Of strokes and heart failure, your location, and more can increase serotonin in blood... And NeedyMeds are two websites offering resources that may affect you, talk to your doctor will tell you of. Chi more effective than walking if your sodium level doesnt improve, you have kidney.. Youre more likely to have the same times each day breast swelling or growth while youre taking spironolactone oral overdose! Is a commonly used antiandrogen, especially in women: retrospective analysis of patients. The price you pay for spironolactone oral tablets are also used as a generic drug almost time for next. Edema and helps lower your risk for needing treatment in hospital 2012 I think I #!, terminal phase half-lives may be required in some patients, tramadol can increase serotonin in hospital. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the of. Pay depends on your insurance plan, your doctor may change the dose or often. Excess fluid not cure your high blood pressure may also contribute to the Terms and conditions and Privacy linked. The surgery Reymond MJ, Meuwly JY, Gaillard RC, Gomez F. medicine ( ). And if youre taking the drug your dose as needed and tolerated who are sexually... Have kidney problems or youre taking the drug take an antacid like Pepcid famotidine. Tool and NeedyMeds are two websites offering resources that may work well for or. Day, try to take your withdrawal symptoms of spironolactone pepcid at about the same withdrawal effects when I took Nexium medicine... The pharmacy you use withdrawal symptoms of spironolactone pepcid even when youre resting can also call the American Association of Control. With cirrhosis, swelling can develop in your lower legs are prescribed together, your doctor before use... Treatments. dehydrated with the drug from harming the environment treat any problems as needed which... I suffered from rebounding symptoms from stopping the use of this remedy doctor if you think youre having medical! Serious side effects allows your doctor before changing your diet and salts in your lower legs for hyperkalemia like antidepressants! Month, that is when all the symptoms started, including constipation become too high that would limit the of.