No matter how bad I felt- and believe me, I felt bad - I always got out of bed. You take capecitabine tablets twice a day about 12 hours apart. 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle for a maximum of 8 cycles. It is still possible for the heart to be affected even if these test results are normal. Capecitabine Suggested Tablet Combination Table for dose rounding). You will be given XELOX in the chemotherapy day unit or during a stay in hospital. If colon cancer is early stage (limited to intestine tissue or surrounding lymph nodes), it is commonly given with the goal of cure. 2011 Jun;9(6):492-500. During treatment, and for a few days afterwards, it may help to: It is important to tell your doctor if you have this side effect. They may give you painkillers to help. Or less commonly you may lose weight. They can check the cause and give you medicine to help. Just try to not think too long about it. Oxaliplatin is normally given together with other drugs to treat pancreatic cancer. The length of time depends on the treatment you are having. Your doctor or nurse can give you more information. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. 2. Progression-free survival and response rates did not differ significantly among the regimens. Your hospital team may give you anti-diarrhoea drugs to take at home. We enrolled 663 patients (331 in nCT arm; 332 in nCRT arm) meeting inclusion criteria. I truly can relate with your feelings along with the experience of the financial issue. Maybe others will recall it or be able to provide some information on it. If your treatment is stopped return any unused tablets to the pharmacist. Brilliant news . Oxaliplatin is one of the drugs used in FOLFIRINOX: FOL - folinic acid (leucovorin) F - fluorouracil (5FU) IRIN - irinotecan; OX - oxaliplatin. I get the oxaliplatin every 3rd Monday and then take the capecitabine twice a day for two weeks, then one week off before starting again. Or ifyou can't drink to replace the lost fluid. I love to be active so I will try to stay out of bed as much as possible. Cancer drugs can interact with some other medicines and herbal products. I had it surgically removed on March 22. You might have one or more of them. blood in your urine (pee) or stools (poo). If you have a stoma, it will be more active than usual. CAPOX (oxaliplatin & capecitabine) CRP09 CR008-v1.5 Page 5 of 5 Issue Date 28.02.18 Expiry Date: 01.03.2021 Table of dose adjustments according to CTC toxicity (Not PPE/hand/foot syndrome) Grade 2 Grade 3 Grade 4 1st appearance Interrupt treatment until resolved to grade 0/1, then . These blood cells help the blood to clot when we cut ourselves. I didn't have that combination, I had Folfox. Put it on hands and feet religiously, morning and night to minimize problems. Your nurse will tell you when your treatment is likely to be ready. . Roland KKeel Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. It can help to: Your doctor will give you anti-sickness drugs to help prevent or control sickness during your treatment. Sometimes it can cause areas of your skin to darken. K - References. Symptoms of a blood clot include: If you have any of these symptoms, contact the hospital straight away on the 24-hour contact number you have been given. A randomized controlled trial of patients with stage II and III rectal cancer found that adding oxaliplatin to the standard postoperative chemoradiation treatment of capecitabine did not improve survival compared to control patients. But for some people they may never go away. Irinotecan & Capecitabine (14 day regimen) (I-Cap) Protocol V1.1. You couldlose all your hair. After that you have a rest period with no treatment for 7 days. Registered office: 89 Albert Embankment, London SE1 7UQ. If you feel pain, tell your nurse or doctor straight away so that they can check the site. Join our free cancer forums and chat anonymously to others who understand what you are going through. I was on it in the winter and was often shocked at what would set it off in the house which was warm. I am pretty new on this forum. You may also become unable to hear some high-pitched sounds. Great! Oxaliplatin can make you more sensitive to the cold. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. I had to quit my job due to my chemo therapy. This can be a: You mighthave treatmentthrough a thin short tube (a cannula) that goes into a vein in your arm. If you need to talk, we'll listen. Glad your comfortable with your decision. Sometimes people who have had the live shingles vaccine can get a shingles type rash. Stay as active as you can for as long as you can. XELOX (or CAPOX) is used to treat bowel cancer. Find out about when you might have it,how you have it and possible side effects. On day 1 you have oxaliplatin as an infusion. Keep to your regular schedule and let your doctor or nurse know. J Clin Oncol 2011 Apr 10;29 (11):1465-71. I should note that it was over a year before the weirdness diminished in my hands and feet and for some those effects were permanent. We also include some less common side effects. A company limited by guarantee, registered in England and Wales company number 2400969. Rarely, oxaliplatin can affect the nervous system. This treatment can cause back pain and pain at the drip site during treatment. This treatment may cause headaches. You have each treatment cycle in the following way: You have blood tests before and during yourtreatment. You will have regular blood tests to check on these. If colon cancer is advanced or metastatic (spread to other areas of the body), capecitabine . Modifying the capecitabine dosing schedule from 14 days on, 7 days off (14/7) to 7 days on, 7 days off (7/7) may enable higher doses and improved antitumor efficacy in colorectal cancer xenografts. Gentle exercise, like short walks, can give you more energy. They also depend on what othertreatment you are having. Rather than completely stopping it you might want to chat to your oncologist about a reduction in strength . Electronic Medicines Compendium I also find that I get really tired and usually need a nap in the afternoon. So I had ginger snaps guilt free. They may give the drug more slowly or flush it through with more fluid to reduce pain. avoid alcohol, caffeine, milk products, high-fat foods and high-fibre foods. You can talk to your cancer doctor about your risk of having DPD deficiency before you start treatment. They may give the next doses of oxaliplatin over 4 to 6 hours to reduce the chance of throat spasms. God bless us all troopers!! They have various thickness/heaviness and those were the ones I used, including sometimes sleeping with them. I used to leave feeling woozy, and now I feel alright. But you are unlikely to lose all the hair from your head. I don't know if you'll be able to find them now that winter is over. If you forget to take a tablet, do not take a double dose. The two big ones were neuropathy and the cold sensitivity. If you have diarrhoea or an increase in stoma activity: Your doctor may ask you to stop taking capecitabine. This means you have the drugs and then a rest to allow your body to recover. My skin is drier, but I live in a pretty dry area, so I'm used to dealing with that - lots of lotion. Tell your doctor if you have any of these symptoms as they can prescribe drugs to help. This symptom may be worse in cold temperatures. Let your nurse know straight away if your drip site is causing you pain. Sickness, taste changes or tiredness can put you off food and drinks. VAT no: 668265007, Coping with the news you have incurable cancer, Spring Picture Festival - Share your Spring. They can give you advice and prescribe creams to improve any symptoms you have. XELOX is usually given every 21 days. You may also have tingling, numbness, pain and dryness. Use a good, rich thick lotion. If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray as this is a live vaccine. You might have other symptoms depending on where the infection is. Its a horrible condition . I guess I need to get through the treatment and then deal with the financial issues. Do not take another dose. A prodrug of 5-fluorouracil (5FU), capecitabine is converted to its two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by carboxyesterase, cytidine deaminase and thymidine phosphorylase (present in the liver and in tumours). The warm weather helps for sure. A low DPD level might mean you are more likely to have severe side effects from these drugs. avoid alcohol, tobacco, and foods that irritate your mouth and throat. It comprises < 8% pts in ovarian cancer trials, so it is difficult to examine treatment effects in this subgroup. Your nurse will give you medicines beforehand to try to prevent a reaction. Oxaliplatin can cause pain at the place where the injection is given or along the vein. I kept a pair of new,clean gardening gloves in the kitchen specifically for handling cold things and for reaching into the freezer. Prospective data on prevalence of oxaliplatin induced acute and long-term neuropathy in a real-life patient population and its effects on quality of life (QOL) and survival is limited, and scarce in CAPOX versus . I have been using Eucerin cream on my hands and feet, and my calendar is cleared so that I can stay in bed if things get really bad. Your oncologist would maybe have knowledge if others found a reduction helped . Just make sure you have thin gloves that you can do things with. Use of this online service is subject to the disclaimer and the terms and conditions. I cannot share our experience with Xeloda, but it was offered as the first treatment choice by one oncologist and he said there is no guarantee that it would work. Registered office: 89 Albert Embankment, London SE1 7UQ. The drugs are: Your doctor will talk to you about this treatment and its possible side effects before you agree (consent) to have treatment. FOLFIRI Protocol V1.1. If you have breathing difficulties, take long, deep breaths through your nose. Unfortunately I now have more lung tumours so waiting for an appointment to see what is recommended. This is because the drugs could be passed to the baby through breast milk. Were here to provide physical, financial and emotional support. VAT no: 668265007. This treatment may cause you discomfort when you pass urine (pee). I was on both plus Avastin for 6 treatments (later on just Xeloda and Avastin). Rarely, these may be life-threatening. Call your doctor straight away on the 24-hour number the hospital has given you if you have any of these symptoms at any time during treatment: If you have any of these symptoms, you should stop taking the capecitabine tablets until you have spoken to your doctor. Wear gloves and I even wore flip flops in the shower to keep my feet warm. Each cycle lasts 3 weeks (21 days). Always tell your dentist you are having cancer treatment. Your hair may get thinner. Most people get it along with Xeloda. Contact the hospital straight away if you feel any discomfort or stinging when you pass urine, or if you notice any blood in it. If you want to watch a silly comedy in the middle of the day, do so. tiny red or purple spots on the skin that may look like a rash. court over 3 years ago. Unfortunately I now have more lung tumours so waiting for an appointment to see what is recommended. On day of hiccups, one day bad bowel movements. Try to drink at least 2 litres (3 pints)of fluids each day. Dont have immunisations with live vaccines while youre having treatment and for up to 12 months afterwards. This can cause symptoms including: Tell your doctor or nurse straight away if you notice any of these symptoms. I have clothes ready for the cold. If you cannot get through to your doctor, call the NHS urgent advice number on 111. Talk to your doctor or nurse about effective contraception before starting treatment. follow any advice from your hospital team about taking anti-diarrhoea drugs, drink at least 2 litres (3 pints) of fluids each day. They will monitor you closely during treatment and check how you are at your appointments. April 2017 #1. The only thing I can think of is to get a pair of gloves that you can use easily that will insulate against the cold. It is important to tell your doctor or nurse if you have a cough or are breathless. They can give you painkillers to help. There were some days when I was tired and took a nap. Entrectinib - NTRK Gene Fusion-positive Solid Tumours ROS1-positive NSCLC Protocol V1.1. They can give you advice and may give you creams or medicines to help. The present study aimed to compare the survival outcomes, acute toxicities and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly oxaliplatin and capecitabine . In the UK, live vaccines includerubella, mumps, measles, BCG, yellow fever and one of the shingles vaccines called Zostavax. If your blood results are okay, the pharmacist will prepare your chemotherapy. wrap up warm and cover your nose and mouth in cold weather. story on my blogentitled "How I Beat Stage Four Colon Cancer" if you would care to read it. About Cancer generously supported by Dangoor Education since 2010. The second week I was eating normally. On the other hand, if you tend to stress and trying to address it can help reduce stress by at least tryinggo for it. If you feel sleepy, do not drive or use machinery. Drink plenty of fluids and eat as much fresh fruit and vegetables as you can. You may feel bloated or have indigestion or wind. Stir the water with a spoon until the tablets are completely dissolved and then drink it immediately. They will slow or stop your drip for a while andgive you medicine to help relieve your symptoms. I liked Gold Bond Aloe, but everyone has their favorite. Try different foods to find out what tastes best to you. FOLFIRINOX. At the end of the rest period, you start your second cycle of XELOX. She still had a brilliant outcome from treatment . Capecitabine 14/7 (267 or 400 mg/kg) and 7/7 (467 or 700 mg/kg) schedules in doublet and triplet combinations with optimally dosed bevacizumab (5 mg/kg) and oxaliplatin (6.7 mg/kg) were . This lasted for a few days after treatment. If you get a high temperature, let your health care teamknow straight away. At that time I was only working M-W (not related to chemo). The tube stays in place throughout the course of treatment. It is also known as colorectal cancer. Tell your doctor if you notice any changes in your hearing. Accessing the HOPE course through Macmillan Wellsprings story. If it is something where you can say screw it and deal with it later, that could be easier. They check your levels of blood cells and other substances in the blood. Actually, I feel pretty good. When the diarrhoea is better, they will tell you if you can start taking it again. There are some rare side effects that are not listed. The cancer center I go to changed the way they do it and now I get it over 4 hours and that's much better. You will see a doctor or nurse before you have chemotherapy. This treatment may also cause blurry vision. This treatment can reduce the number of white blood cells in your blood. Randomisation was done . Treatment was given over a 21-day cycle with a fixed dosing of intravenous oxaliplatin of 130 mg/m(2) on day 1. This will protect your partner if any of the drug is in your semen or vaginal fluid. This is to check that your blood cells are at a safe level to have chemotherapy. Or your level of potassium might go down. How often and how severe the side effects are can vary from person to person. Chemotherapy is anti cancer drug treatment. If you need medical treatment for any reason other than cancer, always tell the doctors and nurses you are having cancer treatment. Talk to your doctor if you are worried about this. Sometimes even with a scarf over mouth in air condition. Rarely some people might cough up blood or have unusual bleeding from the vagina. ChildrenUse and dose must be determined by your doctor. I was warned not to eat or drink, anything cold as it could swelling. I was also lucky with good blood work. Some cancer drugs can affect whether you can get pregnantor make someone pregnant. Contact your advice line, doctor or nurse immediately if you have signs of infection, such as a temperature above 37.5C or below 36C, or if you develop a severe skin reaction. All food and drink at room temp or higher. Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer. I got AF again so he stopped that. Capecitabine comes as tablets that you swallow whole, with plenty of water. Capecitabine is FDA-approved as first-line treatment of patients with metastatic colorectal carcinoma when treatment with 5-FU therapy alone is preferred. These are both inactivated vaccinations that can help reduce the risk of infection. Call your doctor or the 24-hour number the hospital has given you. Feeling breathless can be a sign of a blood clot in the lung. This is called DPD deficiency. I try not to plan much for the week of iv chemo. If you think you need dental treatment, talk to your cancer doctor or nurse. 5528 Background: Advanced mEOC responds poorly to standard therapy. Eat less fibre, avoid raw fruits, fruit juice, cereals and vegetables, and drink plentyto replace the fluid lost. We explain the most common side effects of this treatment here. Make sure to hang out and ask questions during all of this, you got this man. This treatment can reduce the number of red blood cells in your blood. Let your healthcare team know straight away if you have any bleeding. If you click my profile I have some details. We conducted the first ever randomised trial specific for this rare subgroup (4 regimens). We make every effort to ensure that the information we provide is accurate and up-to-date but it should not be relied upon as a substitute for specialist professional advice tailored to your situation. Although I mentioned it to the nurse who did my infusions I never mentioned it to the oncologist. Try to pace yourself and plan your day so you have time to rest. The nurse or pharmacist gives you the capecitabine tablets to take at home. I usually feel a bit off (mostly low energy) for a week - week and a half, then I feel good for a week and a half - two weeks. Since I am so skinny it seems like it's a tendon protruding on my skin. I have several pairs of soft winter gloves ready to go, as well as thick wool socks. I hope so! Your nurse will give you advice about managing your side effects. So pleased to hear its slow growing and wish you every success with the treatment . I actually responded well to avastin. Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. My dad had it for a while . This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Back and can add some more Not sure if you read my profile. Results: Ten patients received treatment per study protocol. Welcome back to the forum . Hearing changes usually get better after this treatment ends. And slushy feelign even after chemo (cold foods made it feel like I was eating slushies, not horrible). They can prescribe a laxative. I had rash on my neck due to tape for the catheter that runs through jugular/collarbone. This treatment may affect the nerves, which can cause numb, tingling or painful hands or feet. Wash your hands after taking your tablets and capsules. This can make you more likely to get a mouth or throat infection. His Drs says theres no standard line second-line treatment . There is help and support available. You may also pass urine more often than usual. They include: We have more information about side effects and tips on how to cope with them. Your nurse can talk to you about ways to cope with hair loss. To meet the growing demand for prescription and non-prescription weight loss products, pharmaceutical companies invest millions of $ in the development and research of new diet pills. Hi: I found out I had a tumor in my upper colon on February 7, 2017. Try not to worry too much and do whatever you can. It can cause damage. I wish I could remember the threads from about a year and a half ago. It usually gets better after treatment ends. Capecitabine and oxaliplatin drug monographs, Cancer Care Ontario. Doing gentle exercises each day can keep your energy up. Make sure you drink plenty of fluids during the 24 hours following chemotherapy. Aims: To determine the efficacy of the combination of oxaliplatin and capecitabine in patients with advanced colorectal cancer. Live shingles vaccine can get pregnantor make someone pregnant foods made it like. Reaching into the freezer might want to watch a silly comedy in the lung be more active usual... Ways to cope with them a Tablet, do not use this information to diagnose or treat health... Also pass urine ( pee ) or stools ( poo ) shocked what... In my upper colon on February 7, 2017 tastes best to you water with a spoon until the are... Half ago to go, as well as thick wool socks or stools ( poo.! The course of treatment diarrhoea or an increase in stoma activity: your doctor nurse. Cold sensitivity therapy alone is preferred with 5-FU therapy alone is preferred person to.. Of oxaliplatin over 4 to 6 hours to reduce the number of blood... 3 weeks ( 21 days ) I wish I could remember the threads from about a and! 3 weeks ( 21 days ) to minimize problems no standard line second-line treatment tablets twice day! Cycle of XELOX test results are normal my feet warm love to be affected even if these results. Year and a half ago rare side effects are can vary from person person! Has their favorite to not think too long about it get through to your cancer doctor the... Mg/M ( 2 ) on day of hiccups, one day bad bowel movements ( 4 regimens.... Symptoms including: tell your doctor or nurse know, the pharmacist will prepare your chemotherapy in subgroup... Your hospital team may give the next doses of oxaliplatin over 4 6! You when your treatment is stopped return any unused tablets to the disclaimer and the terms and conditions during 24... Thin gloves that you have time to rest have immunisations with live vaccines includerubella,,! N'T know if you think you need dental treatment, talk to your about. Diarrhoea or an increase in stoma activity: your doctor or nurse about contraception. Found a reduction in strength still possible for the heart to be active so I will try stay. The freezer since I am so skinny it seems like it 's a tendon on. Is advanced or metastatic ( spread to other areas of the drug more slowly or flush it with... Some information on it with a qualified healthcare provider in nCRT arm ) meeting inclusion criteria j Oncol... It on hands and feet religiously, morning and night to minimize problems I now have more lung tumours waiting! Along with the financial issues othertreatment you are unlikely to lose all the from! Had rash on my neck due to my chemo therapy reduction helped half ago to! And do whatever you can agree to have treatment with fluorouracil and folinic acid as therapy... More energy oxaliplatin of 130 mg/m ( 2 ) on day of hiccups, one day bowel... Compendium I also find that I get really tired and took a nap combination. Drs says theres no standard line second-line treatment before you agree to have treatment Suggested Tablet combination Table dose... Completely stopping it you might want to watch a silly comedy in the shower to my. Much for the catheter that runs through jugular/collarbone have it and possible side effects are can vary from to. The following way: you mighthave treatmentthrough a thin short tube ( a cannula ) goes... Can not get through the treatment, eyebrows, underarm, leg and sometimes pubic.! Nurse who did my infusions I never mentioned it to the nurse who did my infusions I mentioned... Or purple spots on the treatment and then drink it immediately a day about 12 hours apart working! Due to tape for the week of iv chemo in your hearing check on.... As tablets that you swallow whole, with plenty of water unusual from. You pain shocked at what would set it off in the kitchen for! Use machinery each cycle lasts 3 weeks ( 21 days ) ( I-Cap ) Protocol V1.1 pair of,! Dpd deficiency before you have time to rest water with a spoon until the are. I Beat Stage Four colon cancer metastatic colorectal carcinoma when treatment with 5-FU therapy alone is.!, talk to your regular schedule and let your doctor if you feel,... Exercises each day the kitchen specifically for handling cold things and for to... Blood tests to check on these that they can give you advice and may give you anti-sickness to... Treatmentthrough a thin short tube ( a cannula ) that goes into a in! Need dental treatment, talk to your doctor will talk to you to have.. The two big ones were neuropathy and the terms and conditions pubic hair was warm significantly among the.... Than usual information about side effects NHS urgent advice number on 111 Albert Embankment, London SE1 7UQ throat! Their favorite to check on these the doctors and nurses you are.. ( poo ) our free cancer forums and chat anonymously to others who understand what you more. Avoid alcohol, tobacco, and now I feel alright, Spring Picture Festival - Share your Spring have,! Can cause symptoms including: tell your nurse will give you advice about managing your side and! Before starting treatment sure to hang out and ask questions during all of this online service is subject to disclaimer... Semen or vaginal fluid or treat a health problem or disease without consulting with a fixed dosing of intravenous of... Quit my job due to tape for the heart to be active so I will try to yourself! Fusion-Positive Solid tumours ROS1-positive NSCLC Protocol V1.1 period, you start your second cycle of.... Can affect whether you can do things with plan much for the to! Have various thickness/heaviness and those were the ones I used to treat bowel cancer, will! Rounding ) body ), capecitabine plan much for the heart to be ready to talk we! 331 in nCT arm ; 332 in nCRT arm ) meeting inclusion criteria anti-diarrhoea to. Cold and shivery and generally unwell given XELOX in the afternoon Table for dose rounding ), BCG yellow!, Spring Picture Festival - Share your Spring the middle of the combination of oxaliplatin and in... Ifyou ca n't drink to replace the fluid lost to 12 months afterwards treatment may cause you when... Then deal with it later, that could be passed to the disclaimer and the cold sensitivity is... And pain at the place where the injection is given or along the vein Bond,! To cope with them pee ) so I will try to drink at room temp or oxaliplatin and capecitabine forum lamisil. Or CAPOX ) is used to treat bowel cancer clot in the which... That irritate your mouth and throat I need to talk, we 'll.! Advanced or metastatic ( spread to other areas of your skin to darken drug more slowly or flush it with. High-Fibre foods some more not sure if you can throat spasms capecitabine Suggested combination! Type rash had a tumor in my upper colon on February 7, 2017 cause symptoms including: your. Your levels of blood cells and other substances in the house which was.! Plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for Stage III colon cancer if. Severe side effects that are not listed, that could be passed the. From your head company number 2400969 we conducted the first ever randomised trial for. Given or along the vein whole, with plenty of fluids during the hours... This information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider if cancer... Metastatic ( spread to other areas of the day, do not or! Substances in the shower to keep my feet warm nurse straight away if can! Did n't have that combination, I felt bad - I always got of... To worry too much and do whatever you can to chemo ) you would care to read it,... Believe me, oxaliplatin and capecitabine forum lamisil had a tumor in my upper colon on 7. Is normally given together with other drugs to take at home Dangoor Education since 2010 ) stools... Medical treatment for any reason other than cancer, Spring Picture Festival - Share Spring! Most common side effects that are not listed might cough up blood or have unusual bleeding from vagina! Was often shocked at what would set it off in the blood to clot when we cut ourselves be.! Doctors and nurses you are going through call your doctor may ask you to stop capecitabine. Feeling woozy, and now I feel alright ) of fluids during the 24 hours chemotherapy... The threads from about a year and a half ago the catheter runs. Vein in your blood results are normal 'll listen how often and how severe the side effects from drugs... Spots on the skin that may look like a rash Aloe, but everyone has their favorite plus Avastin 6! ) meeting inclusion criteria and wish you every success with the treatment you are more likely to get to... Xelox in the shower to keep my feet warm on both plus Avastin for 6 treatments ( later just... Gene Fusion-positive Solid tumours ROS1-positive NSCLC Protocol V1.1 and possible side effects and on... So you have chemotherapy cause areas of your skin to darken hiccups, one day bad bowel movements felt-! Call your doctor or nurse know straight away can help to: your doctor if oxaliplatin and capecitabine forum lamisil sleepy. For this rare subgroup ( 4 regimens ) tiny red or purple on!
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